Fatigue is common among people with systemic lupus erythematosus (SLE). In some cases, it can affect the ability to perform daily tasks. Some strategies can help manage lupus-related fatigue.

Fatigue is a common symptom of lupus. Fatigue can make you feel extremely tired or like you have no energy.

There are numerous possible causes of fatigue with lupus. There are also a variety of strategies that can help you manage fatigue.

Read on for more information about fatigue with lupus, including its causes, ways to manage it, and more.

Many factors can contribute to fatigue in people with lupus. These can include:

  • inflammation
  • infections, with people with lupus more likely to get infections when they take medication that suppresses the immune system
  • insomnia or other sleeping problems, which could be due to lupus pain or medications
  • stress, which can trigger or worsen lupus symptoms
  • depression, which can occur alongside lupus
  • anemia, which can occur alongside lupus
  • not getting enough calories due to gastrointestinal or kidney problems
  • thyroid problems, such as hypothyroidism and thyroid nodules, which are more common in people with lupus
  • overexertion or doing too much, which may trigger a lupus flare

Taking certain medications for lupus may also cause fatigue. For example, prednisone can lead to sleeping problems and tiredness.

Some pain relief medication can also cause fatigue.

Speak with a doctor if you believe your medication is causing fatigue. It is important to continue taking any prescription medication until a doctor advises otherwise.

Fatigue is a common symptom of lupus. Around 67% to 90% of people with lupus will experience fatigue at some point.

Fatigue with lupus may be constant, or it may come and go.

Around 40% of people with lupus experience severe fatigue persistently.

There are various ways to help manage fatigue with lupus. Examples include:

  • taking steps to improve sleep hygiene, which can include:
    • going to bed and waking up at the same time, where possible
    • sleeping in a dark room
    • keeping the room at a cool, comfortable temperature
    • spending time unwinding and relaxing before bed
    • avoiding looking at screens right before bed
  • speaking with a doctor about hydroxychloroquine, a medication that can help manage lupus symptoms such as fatigue
  • only focusing on activities that are important, and allowing yourself to save certain tasks for when you have more energy
  • listening to your body and taking naps during the day when necessary
  • planning ahead, such as by organizing your clothing the night before or writing lists

Managing the causes of fatigue may also help. Depending on the cause, it may be beneficial to:

  • get enough regular exercise or physical activity, which may help alleviate stress
  • speak with a therapist about depression
  • speak with a registered dietitian to ensure you’re getting enough calories and proper nutrition
  • treating anemia if it is an underlying cause
  • following a treatment plan for lupus, which you can work with your doctor to create

Some medications, such as hydroxychloroquine, may reduce lupus fatigue.

Stress can trigger or worsen symptoms of lupus, including fatigue. Taking steps to manage stress may help.

Getting enough physical activity or exercise may help some people manage fatigue with lupus. However, it is important to listen to your body and rest when you need to.

Some people with lupus may not get enough calories, and this can affect fatigue. Speak with a registered dietitian for advice on ways to meet your caloric needs.

Pain can affect your quality of sleep, and this can lead to fatigue. Some pain relief medications can also cause fatigue as a side effect.

Speak with a doctor for advice on ways to alleviate pain and manage fatigue.

People with lupus commonly experience fatigue. Some possible causes include inflammation, insomnia, infections, anemia, stress, thyroid problems, overexertion, and not getting enough calories.

Fatigue with lupus may come and go, or it may be constant. It can also be severe. Following your treatment plan for lupus and taking medication such as hydroxychloroquine may help.

Other tips for managing fatigue with lupus include improving sleep hygiene, listening to your body, taking naps when necessary, and planning ahead. Addressing any underlying cause will also help.