Nexlizet Interactions: Alcohol, Medications, and Others

Does Nexlizet interact with other drugs?

Before you start taking Nexlizet, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Nexlizet interacts with herbs, vitamins, or supplements, see the “Are there other interactions with Nexlizet?” section.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists drugs that may interact with Nexlizet. Keep in mind that this table does not include all drugs that may interact with Nexlizet. For more information about some of these interactions, see the “Drug interactions explained” section.

When should I avoid Nexlizet?

Certain health conditions or other factors could raise your risk of harm if you take Nexlizet. In such cases, your doctor may not prescribe Nexlizet for you. These are known as contraindications. A contraindication of Nexlizet is:

• If you’ve had an allergic reaction: If you’ve ever had an allergic reaction to Nexlizet or any of its ingredients, your doctor likely won’t prescribe Nexlizet for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Before you start taking Nexlizet, talk with your doctor if the factor above applies to you. Your doctor can determine whether Nexlizet is safe for you to take.

Does Nexlizet interact with alcohol?

Nexlizet is not known to interact with alcohol. But Nexlizet and alcohol can increase the risk of gout and elevated liver enzymes. So you may have an increased risk of these conditions if you drink alcohol during your Nexlizet treatment.

If you have questions about consuming alcohol while taking Nexlizet, talk with your doctor or pharmacist.

Drug interactions explained

Learn more about certain drug interactions that can occur with Nexlizet.

Interaction with statins

Nexlizet can interact with statin drugs, which are used to treat high cholesterol.

Examples of statin medications that may interact with Nexlizet include:

• simvastatin (Zocor)
• pravastatin (Pravachol)

What could happen

Taking certain statins during treatment with Nexlizet can raise your risk of side effects from the statins. These side effects include:

• muscle pain
• muscle weakness
• rhabdomyolysis, a severe condition in which damaged muscle breaks down

What you can do

If you’re taking a statin, tell your doctor before you start Nexlizet. They’ll likely decrease the dosage of your statin. You should not take a higher dose of either medication than your doctor prescribes.

If you take statins during Nexlizet treatment, tell your doctor right away if you have symptoms of muscle problems, such as:

• muscle weakness
• muscle cramping
• muscle pain

If you have questions about taking Nexlizet with statins, talk with your doctor or pharmacist.

Interaction with fibrates

Nexlizet can interact with fibrates, a group of drugs used to lower cholesterol. Some examples of fibrate medications are:

• gemfibrozil (Lopid)
• fenofibrate (Antara, others)
• clofibrate (Atromid-S)

What could happen

Taking fibrates during Nexlizet treatment can increase the risk of gallstones.

What you can do

Before you start Nexlizet treatment, tell your doctor if you take any fibrate medications. They can discuss whether Nexlizet is right for you or provide other treatment options.

Symptoms of gallstones include:

• pain in your back
• pain in your shoulder
• pain on the right side of your body

If you’re taking a fibrate drug with Nexlizet and you develop any of these symptoms, call your doctor right away.

Interaction with corticosteroids

Nexlizet also can interact with corticosteroids. These drugs relieve swelling and irritation. Some examples of corticosteroid medications are:

• prednisone (Deltasone, others)
• methylprednisolone (Solu-Medrol, others)
• hydrocortisone (Cortef, others)
• mometasone (Nasonex)
• prednisolone (Omnipred, others)

What could happen

Taking Nexlizet with corticosteroids can increase your risk of tendon rupture (a torn tendon). Tendons connect muscle with bone or some other structure.

What you can do

Before you start any corticosteroids, tell your doctor that you’re taking Nexlizet. They can determine whether it’s safe for you to take these drugs together. If so, they’ll likely monitor you closely for tendon problems.

Watch for symptoms of problems in tendon areas, such as:

• pain
• swelling
• tearing
• inflammation (usually indicated by redness or pain)

If you experience any of these symptoms in an area where a tendon might be, talk with your doctor right away. If your symptoms are severe or you feel or hear a snap or pop in the area, stop taking Nexlizet and get medical help right away.

Are there other interactions with Nexlizet?

Nexlizet may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that this information does not include all other interactions possible with Nexlizet.

Does Nexlizet interact with supplements?

Before you start taking Nexlizet, talk with your doctor and pharmacist about any herbs, vitamins, or supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Nexlizet and herbs

Nexlizet currently has no reports of interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Nexlizet.

Nexlizet and vitamins

Nexlizet currently has no reports of interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Nexlizet.

Does Nexlizet interact with food?

Nexlizet currently has no reports of interacting with food. If you have questions about eating certain foods during your treatment with Nexlizet, talk with your doctor.

Does Nexlizet interact with vaccines?

Nexlizet currently has no reports of interacting with vaccines. If you have questions about getting certain vaccines during your Nexlizet treatment, talk with your doctor.

Does Nexlizet interact with lab tests?

Nexlizet currently has no reports of interacting with lab tests. If you have questions about having certain lab tests done during your treatment with Nexlizet, talk with the healthcare professional ordering the test.

Does Nexlizet interact with cannabis or CBD?

Nexlizet currently has no reports of interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Nexlizet.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Does my health history affect whether I should take Nexlizet?

Certain medical conditions or other health factors may raise the risk of interactions with Nexlizet. Before taking Nexlizet, talk with your doctor about your health history. They’ll determine whether Nexlizet is right for you.

Health conditions or other factors that might interact with Nexlizet include:

Kidney problems: Nexlizet may cause kidney problems in some people. If you have a history of kidney problems, Nexlizet may worsen them. Due to this risk, be sure to tell your doctor if you have kidney problems before you start Nexlizet. They can discuss whether Nexlizet is right for you.

Liver problems: Nexlizet can cause elevated liver enzymes. This can be a sign of liver damage. If you have a history of liver problems, Nexlizet may worsen them. Tell your doctor if you have liver problems. They can help determine whether Nexlizet is safe for you.

Gout: Nexlizet can increase the uric acid levels in your blood. This can lead to or worsen gout. Before you start Nexlizet, tell your doctor if you have gout. They may order a test to check your uric acid level.

Tendon problems: Nexlizet can cause tendon problems, such as tendon rupture (a torn tendon). If you’ve had tendon problems in the past, your risk of this side effect may be higher. Before you start taking Nexlizet, let your doctor know if you’ve had tendon problems. They can help determine whether Nexlizet is safe for you.

Pregnancy: It’s not known whether Nexlizet is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Nexlizet.

Breastfeeding: It’s not recommended to take Nexlizet while breastfeeding. In animal studies, the drug was shown to pass into the milk of lactating animals. Although it’s not known whether the drug passes into human breast milk, it could cause serious side effects in a child who’s breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction: If you’ve ever had an allergic reaction to Nexlizet or any of its ingredients, your doctor likely won’t prescribe Nexlizet. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

How can I prevent interactions?

Taking certain steps can help you avoid interactions with Nexlizet. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

• whether you drink alcohol or use cannabis
• other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a medication list)
• what to do if you start taking a new drug during your Nexlizet treatment

It’s also important to understand Nexlizet’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you didn’t get paperwork with Nexlizet, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Taking Nexlizet exactly as prescribed can also help prevent interactions.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.