Heat intolerance is a common side effect of many medications, including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs).
Heat intolerance, or heat sensitivity, occurs when you’re unable to regulate your body temperature effectively.
This can lead to extreme temperature shifts that may be unexpected or unusual for your current environment. For example, you may be burning up while those around you are shivering in the cold winter weather.
SSRIs and TCAs can disrupt typical sweating patterns, leading to hyperhidrosis (excessive sweating) or anhidrosis (reduced sweating) in hot conditions.
This can interfere with your body’s ability to cool itself through perspiration, resulting in a heightened sensitivity to heat.
According to a 2022 review, SSRIs and TCAs can raise core body temperature above 106°F (41°C), increasing the risk of heat exhaustion and heatstroke.
You might find it helpful to make a heat safety plan with your prescribing physician and share it with your loved ones so that they can help in the event of a medical emergency.
Consult with a healthcare professional if your symptoms persist or worsen. Do not change or skip doses of your medication without first consulting with your prescribing physician.